Loot is now based on level, biome, tile set and poi tier from what I recall from their explanation on the dev streams.
Biome wise the looting is stage as follows from what I remember, worst to best: forest, desert (and burnt forest in Navezgane), snow, wasteland.
Tile set I think it was: rural, town, city, downtown. (I feel like I'm missing allot of the granularity they put in here)
The enemies you face are also supposed to be adjusted in the same way to add to the challenge for going after the better locations.
So if you're nuts you could try and loot a tier 5 in the downtown of a wasteland city week 1, but don't expect it to be all snuggles and soda pop. 😁