Save corruption is an issue that is being looked into, though I can't get into specifics at this time. I'd try to eliminate any extraneous processes that are running while playing the game, and avoiding sleep/hibernation in the mean time until a fix is released.
Save corruption typically happens when the system is interrupted while writing to a save which happens periodically during a playthrough. One thing you can do after a crash but BEFORE YOU LAUNCH THE GAME AGAIN is move the save file and rename the backup file to the name of the save. It's not a perfect solution but it should work in the mean time. Surely not an optimal solution, but it's the one we have to work with right now.
This still seems more like an overarching system issue in your particular case, and the save corruption issue is something that is being worked on. If you have further issues after that fix is released, please feel free to reach back out.
As far as troubleshooting your system, your best bet would be to start by checking your hard drive(s), memory, and anti-virus health.
Can you post your output log please?