Probably related: If you go into edit a POI to change some switch settings (switch/door/etc.), and that's the only thing you change, it also does not give you a prompt that the prefab needs to be saved. If you exit and go back in, those changes you made were not saved.
Prefab Editor - Changed POI, but Editor Doesn't Indicate Change Needs to be Saved
in Confirmed
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Probably related: If you go into edit a POI to change some switch settings (switch/door/etc.), and that's the only thing you change, it also does not give you a prompt that the prefab needs to be saved. If you exit and go back in, those changes you made were not saved.