Try testing your ram for errors using free Memtest86. I had a similar issue a few years back and faulty ram was the issue. It would crash only for 2 specific games after about 10 - 20 minutes of playtime depending on the game.
Also make sure to re-check the game's installation integrity to make sure there's no corruption or modification anywhere. If you had any mods installed... now would be a good time to get rid of them till you know where the problem is.
And lastly, try disabling any background apps from running while playing the game, including antivirus. There's a few software out there that conflict with the game and causes all kinds of problems including crashes.