I would suspect TFP will need to either a) be continuously creating POIs throughout Alpha, Beta, Gold, forever... or b) come up with a random POI creator that can combine rooms, floors, and other structure elements to produce new POIs on the fly. That would actually be pretty cool, imagine 1 Amigone Funeral Home where the end loot is in the tower, one where it's in a basement, and 1 where it's in the attic as usual.