I love No-Trader runs. I just add recipes for all non-craftable items.
For me, the back and forth of the trader system is the most tedious and gamey aspect of vanilla. Just let me take all the missions and go about my business. I'll be back in a week or whatever. Or give me a time limit, or a zone to clear. Anything but this travelling the same road over and over, checking in between each job. I hate it a lot.
In my perfect game, there would be no traders. All POIs would be Clear and Fetch missions, triggered when I step on the property, one-and-done. Buried Supplies missions would be migrated to the Treasure Map system. Kill the zombies, collect all the MacGuffin parts, save the world. In the final scene, I'll be flying my gyro out of the death zone, homeward bound, when I get clipped by the air drop plane and go down in flames.